diff --git a/lib/livebook/intellisense.ex b/lib/livebook/intellisense.ex
index e25668e9b..d01b489d5 100644
--- a/lib/livebook/intellisense.ex
+++ b/lib/livebook/intellisense.ex
@@ -23,6 +23,13 @@ defmodule Livebook.Intellisense do
           map_binding: (Code.binding() -> any())
         }
 
+  @doc """
+  Clear any cache stored related to the given node.
+  """
+  def clear_cache(node) do
+    IdentifierMatcher.clear_all_loaded(node)
+  end
+
   @doc """
   Resolves an intellisense request as defined by `Runtime`.
 
diff --git a/lib/livebook/intellisense/identifier_matcher.ex b/lib/livebook/intellisense/identifier_matcher.ex
index dfce561d1..35cda1b49 100644
--- a/lib/livebook/intellisense/identifier_matcher.ex
+++ b/lib/livebook/intellisense/identifier_matcher.ex
@@ -99,6 +99,25 @@ defmodule Livebook.Intellisense.IdentifierMatcher do
   @alias_only_atoms ~w(alias import require)a
   @alias_only_charlists ~w(alias import require)c
 
+  @doc """
+  Clears all loaded entries stored for node.
+  """
+  def clear_all_loaded(node) do
+    :persistent_term.erase({__MODULE__, node})
+  end
+
+  defp cached_all_loaded(node) do
+    case :persistent_term.get({__MODULE__, node}, :error) do
+      :error ->
+        modules = Enum.map(:erpc.call(node, :code, :all_loaded, []), &elem(&1, 0))
+        :persistent_term.put({__MODULE__, node}, modules)
+        modules
+
+      [_ | _] = modules ->
+        modules
+    end
+  end
+
   @doc """
   Returns a list of identifiers matching the given `hint` together
   with relevant information.
@@ -438,7 +457,7 @@ defmodule Livebook.Intellisense.IdentifierMatcher do
   end
 
   defp container_context_struct_fields(pairs, mod, hint, ctx) do
-    map = Map.from_struct(mod.__struct__)
+    map = Map.from_struct(mod.__struct__())
     map = filter_out_fields(map, pairs)
 
     for {field, default} <- map,
@@ -619,7 +638,7 @@ defmodule Livebook.Intellisense.IdentifierMatcher do
   end
 
   defp get_modules(node) do
-    modules = Enum.map(:erpc.call(node, :code, :all_loaded, []), &elem(&1, 0))
+    modules = cached_all_loaded(node)
 
     if node == node() and :code.get_mode() == :interactive do
       modules ++ get_modules_from_applications()
diff --git a/lib/livebook/runtime/erl_dist/runtime_server.ex b/lib/livebook/runtime/erl_dist/runtime_server.ex
index d55cbb8c3..77d0f7149 100644
--- a/lib/livebook/runtime/erl_dist/runtime_server.ex
+++ b/lib/livebook/runtime/erl_dist/runtime_server.ex
@@ -307,6 +307,7 @@ defmodule Livebook.Runtime.ErlDist.RuntimeServer do
   @impl true
   def init(opts) do
     Process.send_after(self(), :check_owner, @await_owner_timeout)
+    :net_kernel.monitor_nodes(true, node_type: :all)
     schedule_memory_usage_report()
 
     {:ok, evaluator_supervisor} = ErlDist.EvaluatorSupervisor.start_link()
@@ -349,6 +350,11 @@ defmodule Livebook.Runtime.ErlDist.RuntimeServer do
     end
   end
 
+  def handle_info({:nodedown, node, _metadata}, state) do
+    Livebook.Intellisense.clear_cache(node)
+    {:noreply, state}
+  end
+
   def handle_info({:DOWN, _, :process, owner, _}, %{owner: owner} = state) do
     {:stop, :shutdown, state}
   end
diff --git a/test/livebook/intellisense_test.exs b/test/livebook/intellisense_test.exs
index d485e8c9e..0975938d5 100644
--- a/test/livebook/intellisense_test.exs
+++ b/test/livebook/intellisense_test.exs
@@ -230,6 +230,16 @@ defmodule Livebook.IntellisenseTest do
              ] = Intellisense.get_completion_items("RuntimeE", context, node())
     end
 
+    test "caches all loaded modules" do
+      context = eval(do: nil)
+      Intellisense.get_completion_items("Hub", context, node())
+
+      key = {Intellisense.IdentifierMatcher, node()}
+      assert [_ | _] = :persistent_term.get(key, :error)
+      Intellisense.IdentifierMatcher.clear_all_loaded(node())
+      assert :error = :persistent_term.get(key, :error)
+    end
+
     test "Elixir struct completion lists nested options" do
       context = eval(do: nil)