diff --git a/assets/js/app.js b/assets/js/app.js
index 5695e3fa7..6fb8dcc0c 100644
--- a/assets/js/app.js
+++ b/assets/js/app.js
@@ -18,43 +18,97 @@ import { loadAppAuthToken } from "./lib/app";
 import { settingsStore } from "./lib/settings";
 import { registerTopbar, registerGlobalEventHandlers } from "./events";
 
-const csrfToken = document
-  .querySelector("meta[name='csrf-token']")
-  .getAttribute("content");
+function connect() {
+  const csrfToken = document
+    .querySelector("meta[name='csrf-token']")
+    .getAttribute("content");
 
-const liveSocket = new LiveSocket(
-  window.LIVEBOOK_BASE_URL_PATH + "/live",
-  Socket,
-  {
-    params: (liveViewName) => {
-      return {
-        _csrf_token: csrfToken,
-        // Pass the most recent user data to the LiveView in `connect_params`
-        user_data: loadUserData(),
-        app_auth_token: loadAppAuthToken(),
-      };
-    },
-    hooks: hooks,
-    dom: morphdomOptions,
-  }
-);
+  const liveSocket = new LiveSocket(
+    window.LIVEBOOK_BASE_URL_PATH + "/live",
+    Socket,
+    {
+      params: (liveViewName) => {
+        return {
+          _csrf_token: csrfToken,
+          // Pass the most recent user data to the LiveView in `connect_params`
+          user_data: loadUserData(),
+          app_auth_token: loadAppAuthToken(),
+        };
+      },
+      hooks: hooks,
+      dom: morphdomOptions,
+    }
+  );
 
-// Show progress bar on live navigation and form submits
-registerTopbar();
+  // Show progress bar on live navigation and form submits
+  registerTopbar();
 
-// Handle custom events dispatched with JS.dispatch/3
-registerGlobalEventHandlers();
+  // Handle custom events dispatched with JS.dispatch/3
+  registerGlobalEventHandlers();
 
-// Reflect global configuration in attributes to enable CSS rules
-settingsStore.getAndSubscribe((settings) => {
-  document.body.setAttribute("data-editor-theme", settings.editor_theme);
-});
+  // Reflect global configuration in attributes to enable CSS rules
+  settingsStore.getAndSubscribe((settings) => {
+    document.body.setAttribute("data-editor-theme", settings.editor_theme);
+  });
 
-// Connect if there are any LiveViews on the page
-liveSocket.connect();
+  // Connect if there are any LiveViews on the page
+  liveSocket.connect();
 
-// Expose liveSocket on window for web console debug logs and latency simulation:
-// >> liveSocket.enableDebug()
-// >> liveSocket.enableLatencySim(1000) // enabled for duration of browser session
-// >> liveSocket.disableLatencySim()
-window.liveSocket = liveSocket;
+  // Expose liveSocket on window for web console debug logs and latency simulation:
+  // >> liveSocket.enableDebug()
+  // >> liveSocket.enableLatencySim(1000) // enabled for duration of browser session
+  // >> liveSocket.disableLatencySim()
+  window.liveSocket = liveSocket;
+}
+
+// When Livebook runs in a cross-origin iframe the browser may restrict access
+// to cookies. This is the case in Safari with the "Prevent cross-site tracking"
+// option enabled, which is the default. Without cookies access, the session
+// is not stored, so CSRF tokens are invalid. Consequently, LV keeps reloading
+// the page, as we try to connect the socket with invalid token. To work around
+// this we need to ask to explicitly grant access to cookies, as outlined in (1).
+//
+// (1): https://developer.mozilla.org/en-US/docs/Web/API/Storage_Access_API
+
+if (document.hasStorageAccess) {
+  document.hasStorageAccess().then((hasStorageAccess) => {
+    if (hasStorageAccess) {
+      connect();
+    } else {
+      const overlayEl = document.createElement("div");
+
+      overlayEl.innerHTML = `
+        <div class="fixed top-0 bottom-0 left-0 right-0 z-[1000] px-4 py-8 bg-gray-900/95 flex justify-center items-center">
+          <div class="max-w-[600px] w-full flex flex-col">
+            <div class="text-xl text-gray-100 font-medium">
+              Action required
+            </div>
+            <div class="mt-3 text-sm text-gray-300">
+              It looks like Livebook does not have access to cookies. This usually happens when
+              it runs in an iframe. To make the app functional you need to grant Livebook access
+              to its cookies explicitly.
+            </div>
+            <div>
+              <button id="grant-access" class="mt-6 button-base button-blue">
+                Grant access
+              </button>
+            </div>
+          </div>
+        </div>
+      `;
+
+      document.body.appendChild(overlayEl);
+
+      const grantAccessButtonEl = overlayEl.querySelector("#grant-access");
+
+      grantAccessButtonEl.addEventListener("click", (event) => {
+        document
+          .requestStorageAccess()
+          .then(() => window.location.reload())
+          .catch(() => console.log("Access to storage denied"));
+      });
+    }
+  });
+} else {
+  connect();
+}